Endocrine treatment of advanced metastatic prostate cancer is becoming the preferred method of treatment. Endocrine therapy of stage iv prostate cancer cure is currently the main method:
1.Estrogen By inhibiting the secretion of pituitary LH, thus inhibiting secretion of slaughter-one, in 1-3 weeks which can reach castration levels of serum ketone generation. Diethylstilbestrol (DES) was an early prostate cancer treatment, because of serious cardiovascular reactions, limiting their use. Recently, the discovery of diethylstilbestrol can induce apoptosis of androgen-dependent cells, there is a tendency to re-evaluation of DES.
2.LH-RH analogues A transient stimulation LH secretion, followed by inhibition due to decreased pituitary response to LH secretion, is to achieve the purpose of medical castration. Such as: enantone.
3.Anti-androgen drugs Through competitive binding of androgen receptor, it inhibit androgen effects on gene expression in cancer cells. Such as: flutamide.
4.Resection Resection Jae 9, you can make one cover in serum by 90%, which is the most commonly used endocrine treatment in the world.
With regard to endocrine therapy of the stage iv prostate cancer cure, prostate cancer, further deterioration in the short term, leading to the ultimate cause of death of patients, there are two kinds of explanation:
1.Adrenal glands produce androgen substrate, dehydroepiandrosterone (DHEA), the prostate can be effective in the low activity.
2.That the existence of androgen-dependent cell.
Failure of endocrine therapy for prostate cancer may be related to the above two cases, there is the relationship, especially the latter is more difficult to resolve the current proposed solutions.there should be an deeper study for the endocrine therapy of stage iv prostate cancer cure.