Hear the authors of two high impact papers in Nature and Science Translational Medicine describe how long non-coding RNAs provide new therapeutic avenues in cancer and heart disease.
Prof. Thum, Director of the Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Germany describes results from the Science Translational Medicine paper demonstrating that silencing the lncRNA Chast in mouse models using Antisense LNA™ GapmeRs prevents cardiac hypertrophy and even reverses established cardiac disease.
Prof. Marine, Head of the VIB Laboratory for Molecular Cancer Biology, K.U. Leuven, Belgium presents results from the Nature paper showing that melanoma cancer cells are addicted to the lncRNA SAMMSON. They demonstrate that Antisense LNA™ GapmeRs targeting SAMMSON significantly suppress tumor growth in xenograft melanoma models, and also increase the sensitivity of melanoma to MAPK-targeting therapeutics.